About Xyzagen

Bioanalysis, nonGLP Pharmacokinetics, GLP Toxicokinetics, Clinical Pharmacology and Drug Development Consulting

Christopher Crean

CEO, Principal Consultant

Christopher Crean

CEO, Principal Consultant

Christopher Crean is the founder, CEO and Principal Consultant at Xyzagen, Inc. He also founder of 1st Order Pharmaceuticals, which successfully advanced 1OP-2198 to an FDA PreIND Meeting and divestment to Xenon Pharmaceuticals, Inc. 

Prior to his work as a consultant, Mr. Crean was North American Head of Clinical Pharmacology and Nonclinical Development at Valeant Pharmaceuticals and has worked as a senior scientist at Big Pharma, venture-backed biotech (Inspire Pharmaceuticals & Icagen) as well as contract research firm MPI Research.

Mr. Crean is aware of the physical and logistical challenges of biotech companies with limited resources and as such is a qualified pharmaceutical professional, with experience developing integrative early phase drug discovery/translational research programs; incorporating nonclinical pharmacokinetics and drug metabolism, GLP toxicokinetics and Phase 1 Clinical Pharmacology studies (study design, operations, and pharmacokinetic analysis).

our history

Xyzagen’s broad experience is backed by its founder’s more than 25 years of ‘in the trenches’ drug development experience. Mr. Crean has worked for large toxicology companies, large pharma, venture backed biotechs, early IPO biotechs and lean R&D focused midsized pharma before transitioning to consultant and starting his own biotech. In addition to founding Xyzagen, Mr. Crean is also Founder, President and CSO for 1st Order Pharmaceuticals, which successfully divested its single asset, 1OP-2198, a Kv7 channel opener, to Xenon Pharmaceuticals in 2017, now called XEN1101. Prior to championing 1OP-2198, Mr. Crean was a key member of the international GKS/Valeant team that obtained regulatory approval of POTIGA/TROBALT (ezogabine/retigabine) worldwide as well as working on competitive Kv7 channel molecules to retigabine at Icagen in the late 1990s. He’s also supported critical Nonclinical/Clinical Pharmacology/Biopharmaceutics project aspects for the following products; AZASITE, ELESTAT, LACRISERT, TIMOPTIC, MACUGEN, XENAZINE, APLENZIN, SYPRINE, JUBLIA and CARDIZEM CD. Mr. Crean has been involved in canceling early discovery through clinical phase 2 programs in pain, epilepsy, glaucoma, dermatology and cardiology when they didn’t meet critical scientific endpoints. Our CEO has taken part in programs that did not/have not gain(ed) FDA approval in therapeutic areas of dry eye (Prolacria), neonatal hyperbilirubinemia (Stannsoporfin), myelofibrosis (Imetelstat) and hepatitis C (Taribavirin), thus knows the cost constraints and R&D challenges that early stage companies and lean biotechs face in developing their own drugs.

job opportunities

Xyzagen is growing and is always accepting CVs from qualified individuals within the fields of animal husbandry and pharmacology, bioanalysis, drug metabolism and pharmacokinetics that are interested in joining our team. We will keep your CV in our database and out in the case of a strong fit in our future positions. For any of our current positions, please submit your CV.

Job location:

Pittsboro, NC 27312

Employment type:

Full time or Part time

Job Description

Xyzagen (Zi*Za*Gen) is a contract research and consulting organization focused on early discovery pharmacology, pharmacokinetics, drug metabolism and bioanalysis under its contract research services.  It also provides Clinical and Nonclinical Pharmacology and Pharmacokinetic and Drug Development consulting services to its clients. We support clients ranging from early stage seed funded companies emerging from academia, recently venture backed biotechs, to mid/large pharmaceutical companies. Additionally, we act as a 3rd party pharmacokinetics/toxicokinetics analyst to other contract research & consulting organizations (CRCOs).

We are seeking bright, highly-motivated, and organized individuals who are interested in joining a dynamic and intellectually challenging growing CRO. Successful candidates will be optimistic, solutions-oriented, accountable, and open-minded with a positive, can-do attitude and a strong ability to solve problems.

The Research Technician will perform rodent (mouse and rat) research in the laboratory focusing on pharmacology and pharmacokinetic studies. This position will be responsible for animal husbandry and maintaining the vivarium and participating study design, investigation and data collection and tabulation for client studies.  For the right candidate, there are opportunities to learn bioanalytical techniques of drug extraction from biological fluids and tissues and concentration analysis by mass spectrometry.

Job Requirements

Must have previous experience working with animals, be able to understand and follow the Institutional Animal Care and Use Committee (IACUC) guidelines and policies and study specific protocols. Must be willing to work hard in a very physical environment. Qualified applicants must have a demonstrated ability to work well with others. Requires a demonstrated ability to effectively communicate.

The ideal candidate will have a Bachelor’s or Associate’s degree in biological science, or a related field. The position requires an understanding of basic laboratory techniques, strong attention to detail, ability to manage multiple and rapidly changing priorities, and strong communication skills.

– understanding and previous use of standard software and statistical analysis is preferred (e.g. Microsoft Office, Graph Pad Prism)

– general maintenance of laboratory and supplies lists

Job location:

Pittsboro, NC 27312

Employment type:

Full time or Part time

Job Description

Xyzagen (Zi*Za*Gen) is a contract research and consulting organization focused on early discovery pharmacology, pharmacokinetics, drug metabolism and bioanalysis under its contract research services.  It also provides Clinical and Nonclinical Pharmacology and Pharmacokinetic and Drug Development consulting services to its clients. We support clients ranging from early stage seed funded companies emerging from academia, recently venture backed biotechs, to mid/large pharmaceutical companies. Additionally, we act as a 3rd party pharmacokinetics/toxicokinetics analyst to other contract research & consulting organizations (CRCOs).

We are seeking bright, highly-motivated, and organized individuals who are interested in joining a dynamic and intellectually challenging growing CRO. Successful candidates will be optimistic, solutions-oriented, accountable, and open-minded with a positive, can-do attitude and a strong ability to solve problems.

The Bioanalytical Scientist will develop LC/UV and LC/MS/MS bioanalytical methods for fluids and tissue extraction for client based contract research studies.  For the right candidate, there are opportunities to cross functionally learn in vivo pharmacokinetic studies and run Phoenix WinNonLin pharmacokinetic software.  The right candidate may also be client facing and provide consulting experience in their area of expertise of bioanalytical method development and analysis.

Job Requirements

Must have previous experience working with Sciex Analyst 1.6 or higher and experience with Sciex 4000 triple quad mass spectrometers and maintenance of instrument.  Must be willing to work hard in a very physical environment. Qualified applicants must have a demonstrated ability to work well with others. Requires a demonstrated ability to effectively communicate.

The ideal candidate will have a Bachelor’s degree or higher in biological science, or a related field with at least 2 years of instrument experience.

– understanding and previous use of standard software and statistical analysis is preferred (e.g. Microsoft Office, Graph Pad Prism)

– reporting of concentration data and tabulation for reports

– general maintenance of laboratory and supplies lists

Job location:

Pittsboro, NC 27312

Employment type:

Contract

Job Description

Xyzagen (Zi*Za*Gen) is a contract research and consulting organization focused on early discovery pharmacology, pharmacokinetics, drug metabolism and bioanalysis under its contract research services.  It also provides Clinical and Nonclinical Pharmacology and Pharmacokinetic and Drug Development consulting services to its clients. We support clients ranging from early stage seed funded companies emerging from academia, recently venture backed biotechs, to mid/large pharmaceutical companies. Additionally, we act as a 3rd party pharmacokinetics/toxicokinetics analyst to other contract research & consulting organizations (CRCOs).

We are actively identifying experienced senior-level (associate director through VP) drug development professionals with regulatory drug development experience for an exciting opportunity to expand their consulting experience and clientele and collaborate with our growing firm in nonclinical and clinical drug metabolism, bioanalysis, biomarker development and pharmacokinetics.

Consultants will have the freedom to develop their own client base while contributing to Xyzagen’s growing clientele base. Xyzagen’s business model offer consultants an opportunity to be on the entry level with new clients through Xyzagen’s industry offering of First-in-Rodent™ PK. This unique opportunity provides individual senior consultants an opportunity of being associated with an established firm while simultaneously maintaining their independence and core client base.

Job Requirements

The consultants will be experts in nonclinical and clinical PK, and PK/PD translational science concepts as well as have knowledge of drug metabolism, physiology, and human and animal PK studies.  Individuals with advanced degree (MS, Ph.D., PharmD) and 5+ years of corporate experience within a senior role.

  • Experience in Xyzagen’s core therapeutic areas of Ophthalmology, Anti-infectives, Neurology and Pain are preferred but not required.
  • Experience in biomarker, and biologic assay development preferred but not required.