First-in-Rodent Capabilities
Xyzagen’s First-in-Rodent® services reflect more than just in vivo testing—they’re a philosophy rooted in accelerating candidate selection and reducing downstream risk.
Early Drug Development, Done Right
At Xyzagen, we don’t just run rodent studies—we embed directly into your program, integrating wet lab, pharmacology, in vivo services, PK analysis, and modeling & simulation to deliver the insights you need faster. As both a consultancy and a boutique CRO with in-house vivarium and bioanalytical capabilities, we bring a seamless blend of science and strategy that helps you make confident, data-driven decisions in early development.
Why Work With a Boutique Drug Development Consultant?
Making the right decisions during candidate selection and IND preparation can make or break your program. Xyzagen expands your core scientific team with senior-level pharmacologists and pharmacokineticists who work directly with you from discovery through the Pre-IND meeting—and continue supporting clinical pharmacology, PopPK, and quantitative medicine through late-stage development and the Pre-NDA milestone.
At Xyzagen, our First-in-Rodent® (FIR) studies provide early-stage in vivo pharmacokinetic (PK) and metabolism insights that guide smarter compound selection and streamline IND-enabling programs. These studies are designed to help you evaluate systemic exposure, optimize formulation strategies, and identify liabilities before advancing into more costly development stages.
Our Strategic Approach for Early Discovery Studies
With decades of collective expertise, Xyzagen brings a unique perspective to early toxicokinetics (TK). We don’t just design studies—we help you maximize the insights gained from First-in-Rat or First-in-Mouse programs. This approach goes beyond compliance to extract the most meaningful data possible at the earliest stages, informing on exposure, duration of exposure, dose selection, potential safety margins, and the transition to first-in-human trials.
First-in-Rat®
Accelerated compound evaluation through our unique focus on data collection & integration with predictive PK/PD Pharmacology models.
First-in-Mouse®
Specialized in vivo screening tailored for informed client decisions—linking pharmacokinetic (PK) and pharmacodynamic (PD) endpoints to streamline go/no-go calls.
Data Integration
Holistic synthesis of in vitro and in vivo findings that enhances the predictive value of early discovery, supporting smarter, more informed program progression.
Partner with Xyzagen
Xyzagen’s First-in-Rodent capabilities are designed to move your discovery program forward with speed and scientific rigor. Contact us to learn how we can help strengthen your early development strategy.
