Pharmacology Models
Xyzagen’s pharmacology models go beyond standard testing to deliver predictive, translational insights that bridge discovery and clinical development.
What Are Pharmacology Models?
Pharmacology models are experimental systems—either in vitro or in vivo—used to evaluate how a drug interacts with its biological target, alters disease pathways, or influences behavior These models are essential for understanding efficacy, safety, and mechanism of action before clinical testing begins. When designed with translational intent, pharmacology models can predict how a compound will perform in humans and guide critical development decisions.
Translating Discovery into Predictive Pharmacology
At Xyzagen, we translate discovery into predictive pharmacology through the design of models grounded in translational intent—bridging discovery and clinical development to generate data that drives informed decision-making. Our integrated approach connects in vitro and in vivo studies to inform dosing, formulation, and therapeutic potential, helping sponsors advance candidates with greater confidence.
Pharmacology Studies at Xyzagen
We specialize in tailored nonclinical pharmacology solutions across diverse therapeutic areas, supporting small molecules, biologics, and emerging modalities. Our integrated approach combines pharmacology, bioanalysis, and model-informed strategies to deliver actionable data that accelerates development timelines and de-risks early decisions. With extensive expertise in ophthalmology and neurology, Xyzagen offers translationally relevant models that replicate complex disease mechanisms in the eye and central nervous system—enabling predictive evaluation of efficacy and safety for therapies targeting retinal disorders, neurodegenerative diseases, and pain pathways.
Integrating exposure, biology, and disease relevance, we apply these advanced model-development principles across any therapeutic area, delivering mechanism-aligned, translational pharmacology solutions far beyond CNS and ocular indications.
Core Pharmacology Model Capabilities
By integrating pharmacokinetic sampling into in vivo pharmacology studies, Xyzagen directly links pharmacodynamic effects to measured drug exposure in plasma and target tissues. This process enables quantitative exposure–response analysis, allowing in vivo outcomes to be interpreted in the context of in vitro potency, target engagement, and mechanistic pharmacology. Our core pharmacology model capabilities include:
In Vitro & In Vivo Pharmacology Support
Integrated assays for mechanism-based and functional studies.
Neurology & Pain Models
Translationally relevant rodent models for CNS disorders and pain management.
Pharmacology Models: Validated, In Development, & Emerging
Xyzagen’s integrated model and boutique consultancy approach unites strategy, science, and execution within a single, cohesive framework. Our specialization in early drug development allows us to deliver highly translational, decision-enabling data with speed and precision.
Leveraging decades of combined experience in neurology, pain, and ocular pharmacology, Xyzagen has established an expanding catalog of rodent disease models. Each model is supported by our in-house bioanalysis, PK/PD expertise, and data interpretation capabilities to ensure results that stand up to regulatory and translational scrutiny.
Validated Models
Epilepsy/Seizures
MES and PTZ
Local Inflammation/Nociceptive Pain
Thermal sensitivity, acetic acid-induced pain, formalin-induced pain, Carrageenan-induced paw edema
Neuropathic Pain
Rat Chemotherapy-induced Neuropathy
Xyzagen is continuously expanding its preclinical capabilities through the development and validation of new models, supported by the expertise and tools needed to assess disease-relevant behaviors in the following areas:
Alzheimer’s Disease
Anxiety
Autism Spectrum Disorder
Autoimmune Ocular Disease
Cognitive Function
Corneal Wound Healing
Depression
Diabetic Retinopathy
Dry Eye Disease
Epilepsy
Gene Therapy Pharmacology
Inflammatory Disease
Inflammatory Pain
Motor Coordination
Neuroinflammation
Neuropathic Pain
Nociceptive Pain
Ocular Permeability
Retinal Degeneration
Schizophrenia
Uveitis
And many more
Why Choose Xyzagen?
Every study is led by senior scientists with deep experience in translational pharmacology and nonclinical experimental design. We combine scientific rigor with operational flexibility, ensuring each model is aligned with your specific therapeutic goals. From early target validation through preclinical safety assessment, Xyzagen delivers the data-driven insights needed for confident progression to IND.
Contact Us
Discuss your pharmacology model needs with our team. We’ll help design a study plan aligned to your therapeutic area and development goals.
