Neurology & Pain Models
Xyzagen’s CNS and pain models provide translational insights into efficacy, mechanism, and safety to de-risk neurotherapeutic development programs.
Comprehensive Neurology & Pain Pharmacology Models
Xyzagen specializes in CNS and pain pharmacology models that generate actionable, translational data to guide neurotherapeutic development. Our in vivo models assess efficacy, mechanistic effects, and pharmacological response, helping clients reduce late-stage attrition while advancing programs from discovery through preclinical development.
In Vivo CNS Models
Xyzagen’s in vivo CNS models are designed to evaluate seizure susceptibility, pharmacological efficacy, and exposure-response relationships in translationally relevant disease states.
Representative CNS Models:
Acute Seizure:
Maximal electroshock-induced (MES), Pentylenetrazol (PTZ)-induced, 6-Hz-induced
Chronic Seizure:
Lithium-pilocarpine-induced, Kainic acid-induced, Electroshock kindling
In Vivo Pain Models
Chronic and acute pain remain major challenges in drug development. Xyzagen offers a portfolio of in vivo pain models to evaluate nociceptive, neuropathic, and inflammatory mechanisms, as well as opioid and non-opioid analgesics.
Representative Pain Models:
Acute Pain:
Thermal sensitivity, Formalin-induced pain, Acetic Acid-induced pain
Neuropathic Pain:
Spinal nerve ligation (SNL), Chronic constriction injury (CCI), Chemotherapy-induced pain
Inflammatory Pain:
CFA-induced arthritis, Carrageenan models
Analgesia Studies:
Evaluation of opioid and non-opioid interventions
Behavioral & Biomarker Analyses
To enhance translational relevance, our studies incorporate behavioral assessments, and biomarker analyses. This integrated approach ensures data capture that directly informs clinical strategies and supports decision-making.
Why Choose Xyzagen for Neurology & Pain Models?
Our team of senior scientists combines CNS expertise with operational flexibility, providing robust, reproducible models tailored to your therapeutic goals. From early target validation to mechanistic studies, Xyzagen delivers data-driven insights that de-risk development and accelerate progression to clinical testing.
Contact Us
Discuss your neurology or pain pharmacology needs with Xyzagen. We’ll help design a customized study plan that supports your program goals.
