Ophthalmology Models
Translating ophthalmology research into clinical success with targeted expertise and strategic insight.
Comprehensive Ophthalmology Pharmacology Models
Xyzagen’s ophthalmology models provide translational, nonclinical data to guide drug development for retinal, corneal, and anterior segment diseases. We can assess ocular PK, safety, and efficacy, helping clients advance programs for AMD, glaucoma, diabetic retinopathy, dry eye disease, and other ocular indications.
In Vivo Ophthalmology Models
Our in vivo ophthalmology capabilities evaluate efficacy, mechanism of action, and pharmacokinetics across multiple ocular tissues. Representative models include:
Glaucoma:
Intraocular pressure elevation, Optic nerve crush
Diabetic Retinopathy:
STZ-induced hyperglycemia models
Corneal & Dry Eye:
Tear film, Corneal abrasion, MGD-induced models
In Vitro Ophthalmology Capabilities
We offer in vitro analysis of corneal permeability using Franz cells. This allows for the assessment of drug penetration, which can provide information on the mode by which the drug is delivered/transported to its target within the eye
Ocular PK, Functional, & Mechanistic Analyses
We integrate ocular PK and drug distribution studies via intravitreal, topical, and systemic routes. Additional analyses include histopathology, biomarker quantification, and functional vision tests—providing mechanistic insight to support regulatory submissions and clinical translation.
Why Choose Xyzagen for Ophthalmology Models?
Xyzagen combines ocular pharmacology expertise with robust study design and operational flexibility. From early target validation to mechanistic studies, our team delivers data-driven insights that inform safe and effective progression to clinical testing.
Contact Us
Need a custom ophthalmology model for your compound? Contact Xyzagen to discuss a tailored study plan for your program.
