ADME Studies
Comprehensive in vitro and in vivo ADME studies to support pharmacokinetics, safety, and formulation strategies.
What Are ADME Studies and Why They Matter
ADME—short for Absorption, Distribution, Metabolism, and Excretion—refers to the processes that determine a drug’s fate in the body. Understanding these properties is essential to evaluating how a compound is absorbed into circulation, where it travels, how it is metabolized, and how it is ultimately eliminated.
ADME studies help predict a drug’s pharmacokinetic (PK) profile, optimize dosing strategies, and identify potential safety concerns early in development. These data also support regulatory submissions and guide decisions in lead optimization, formulation, and toxicology studies.
ADME Studies at Xyzagen
At Xyzagen, we offer comprehensive ADME studies through our in-house wet lab and integrated preclinical platform. Our in vitro and in vivo capabilities are designed to generate high-quality, decision-enabling data with rapid turnaround.
We also augment physiologically based pharmacokinetic (PBPK) modeling by generating critical in vitro data that may be missing from a client’s internal studies. These customized studies strengthen model predictions and inform better dosing and formulation strategies.
Core ADME Capabilities
From early discovery to IND-enabling studies, we provide expert support across all aspects of ADME (absorption, distribution, metabolism, and excretion) to guide PK profiling, compound screening, formulation, and biomarker strategies.
In Vitro ADME Assays
Our in vitro assays help predict how a drug candidate will behave in vivo—reducing reliance on animal studies and enabling early optimization of compound properties. Xyzagen offers a wide range of industry-standard assays, including:
- Metabolic stability using hepatocytes, microsomes, and S9 fractions
- CYP450 inhibition and induction to assess DDI potential
- Plasma protein binding for distribution prediction
- Permeability assays (e.g., Caco-2) for intestinal absorption potential
- pH stability and solubility profiling
In Vivo ADME Studies
Our in vivo ADME studies evaluate the full pharmacokinetic (PK) profile of your compound in relevant animal models—providing critical data on systemic exposure, tissue distribution, and clearance pathways through:
- Absorption and oral bioavailability assessments
- Tissue distribution studies via whole-body sampling
- Excretion profiling through urine, feces, and bile collection
- Mass balance and metabolite recovery studies
Bioanalytical Support for ADME Studies
Quantitative bioanalysis is a critical pillar of ADME research. Xyzagen supports your studies with high-sensitivity LC-MS/MS and ligand-binding assays for accurate drug quantification, including:
- Plasma, tissue, urine, and feces analysis
- Support for pharmacokinetic, toxicokinetic, and DMPK studies
- Method development and assay transfer for GLP validation
- High-throughput workflows with rapid turnaround to support discovery-stage decisions
Why Choose Xyzagen for Your ADME Studies?
Xyzagen delivers more than data—we provide actionable insights. With a tightly integrated lab infrastructure, First-in-Rodent® platforms, and a team of seasoned pharmacokinetics experts, we offer:
Contact Us
Partner with Xyzagen to accelerate your path from lead optimization to clinical readiness. Contact us today to learn how our ADME studies can help you make informed development decisions with confidence and speed.
