Pharmacogenomics & Biomarker Analysis
Translating genomic data into actionable insights for drug discovery, target validation, and precision medicine.
The Role of Pharmacogenomics in Drug Development
Genomics and molecular biology play a crucial role in understanding disease mechanisms, predicting drug response, and optimizing therapeutic strategies. Pharmacokinetics (PK) can utilize these techniques when studying how genetic variations, such as gene mutations and polymorphisms, affect an individual’s response to drugs including how they are absorbed, distributed, metabolized, and eliminated (ADME).
These differences can impact enzyme activity, drug transporter function, and susceptibility to side effects, ultimately influencing dosing, efficacy, and safety. From early-stage discovery to clinical development, genomic analysis enables researchers to uncover molecular drivers, identify patient subgroups, and develop targeted treatments.
Genomics & Biomarker Analysis at Xyzagen
At Xyzagen, we offer a comprehensive suite of genomic and molecular biology services to accelerate drug development and precision medicine research. Our services are designed to support a range of applications including target identification, pharmacogenomics, and companion diagnostics.
With expertise spanning everything from initial DNA/RNA extraction and qPCR to final sample analysis and bioinformatics, our team helps uncover genetic and molecular signals that drive disease and influence drug efficacy. We tailor each study to your development stage and scientific goals, ensuring high-quality data and interpretation.
Core Capabilities
Xyzagen’s genomics laboratory provides end-to-end support for discovery-phase genomic and molecular biology studies. From sample processing to data analysis, our team applies advanced tools in DNA/RNA preparation, molecular assays, and bioinformatics to help uncover genetic and molecular signals that drive disease and inform early drug development decisions.
DNA/RNA Preparation
Samples can be obtained from cells or whole tissue. Purified products can be used for gene expression analysis or sent for sequencing.
- Extraction
- Purification
Molecular Assays
Offering expertise in the development, optimization, and validation of complex molecular assays using RT-qPCR, we collaborate with your team to ensure your project is a success.
- Custom PCR Primer Design
- Custom Real-Time qPCR Amplification
- Target Gene Expression Analysis
- Preclinical Biodistribution
Bioinformatic Analysis
Analysis of raw genomic sequence data using analytical software tools and standard file formats. Our customized bioinformatics services are tailored to meet the needs of the client, but generally include:
- Data Quality Control (QC)
- Reference Genome Alignment
- Genome Annotation
- Variation Annotation
How Genetics Influence Drug Response
Genetic differences in enzymes, such as cytochrome P450s, can influence how quickly or slowly a drug is metabolized—affecting both its effectiveness and risk of toxicity. Some individuals may require higher doses to achieve therapeutic effects, while others may be at risk of adverse reactions at standard doses.
A person’s genetic makeup may predispose them to certain side effects or influence how well a therapy works. Pharmacogenomics allows drug therapy to be tailored to a person’s genetic profile—improving efficacy, reducing adverse reactions, and supporting more precise, personalized medicine.
Why Choose Xyzagen for Genomics & Biomarker Analysis?
Xyzagen provides flexible, fit-for-purpose solutions that integrate seamlessly into your discovery or development pipeline. Our team partners with you to deliver:
Contact Us
From hypothesis generation to clinical validation, our genomics lab helps turn data into direction. Contact us to learn how our genomics and biomarker services can support your next discovery or development milestone.
